Any region of skin that differs in colour, shape, size, or texture from the surrounding skin is referred to as a skin lesion. Skin lesions are relatively prevalent and frequently develop from localised skin injury, such as contact dermatitis or sunburns. While others, including infections, diabetes, and autoimmune or genetic illnesses, might be symptoms of underlying conditions. Skin lesions are generally benign and harmless, but some of them have the potential to develop into skin cancer because they are malignant or premalignant. There are two basic categories of skin lesions: primary and secondary. Primary skin lesions are those that develop on previously healthy skin and have a known aetiology. Freckles, moles, and blisters are a few typical examples of primary skin lesions. On the other hand, secondary skin lesions emerge from a primary skin lesion as it progresses or as a result of traumatising manipulation, such as scratching or rubbing. Crusts, sores, ulcers, and scars are a few examples of secondary skin lesions. Skin lesions can appear in a wide range of sizes, shapes, and styles. Additionally, skin lesions can manifest singly, in clusters, locally in one part of the body or all over. Patches are similar to macules but greater than 1 cm in diameter. Macules are flat, well-circumcised lesions that are up to 1 cm (0.39 inches) in diameter. Plaques resemble papules but are greater than 1 cm in diameter. Papules are raised lumps. A wheal is a smooth papule or plaque that occasionally emerges and vanishes and is temporary. Examples of skin lesions that can be inherited or acquired as a consequence of different conditions include moles and birthmarks. These include bacteria, fungi, and viruses including Candida albicans, as well as human immunodeficiency virus (HIV), human papillomavirus (HPV), and herpes simplex virus (HSV). Other factors that can result in skin lesions include allergies, contact with irritants, exposure to the sun without protection, severe burns, insect bites, poor circulation, vitamin deficiencies, systemic illnesses such as cancer, several viral disorders, liver and renal disease, and autoimmune diseases. Depending on the type of skin lesion and whether malignancy is present, the treatment might vary. Some benign lesions might not even require treatment; instead, they can be managed with routine checkups with a dermatologist or family doctor.In addition to laser therapy, cryotherapy, phototherapy, and surgical excision, benign skin lesions may require topical drugs such as retinoids, corticosteroids, or antimicrobials. Treatment options may also target the underlying cause if a systemic condition is to blame for the skin lesion.