Infections with bacteria, fungus, viruses, or parasites can result in skin conditions. Group A β-hemolytic streptococci and Staphylococcus aureus are the most frequent bacterial skin pathogens. The most prevalent viral skin condition is herpes simplex. Trichophyton rubrum is the most frequent dermatophytic fungus responsible for skin and nail infections. Primary skin infections are brought on by a single pathogen, generally affect normal skin, and have a distinctive clinical appearance and illness history. Common kinds include boils, folliculitis, and impetigo. The most prevalent main skin pathogens are coryneform bacteria, β-hemolytic streptococci, and S. aureus. Typically, an insect bite or other skin breach allows these germs to enter. Measles, varicella, gonococcemia, and staphylococcal scalded skin syndrome are a few examples of systemic diseases that entail cutaneous symptoms brought on either by the pathogen or by toxins. Due to their high affinity for keratin, dermatophytic fungi can infiltrate the skin, hair, and nail keratinized tissue. Skin that is already ill develops secondary infections. Clinical manifestation and prognosis of these infections differ depending on the underlying illness. Examples include toe web infection and intertrigo. Erythema, edoema, and other indicators of inflammation are typical symptoms of skin infections. It is possible for pus- or fluid-filled vesicles or bullae to develop in specific areas. Lesions can also be scaling without any evident inflammation. Nail infections result in thickening of the nail plate and discolouration of the nail. It could be beneficial to wash and degerm the skin with a soap or detergent that contains an antibacterial component. Additionally useful are keratinolytic treatments like topical salicylate and drying agents like aluminium chloride. Some infections can be treated with topical antimicrobials, but individuals with severe illness may require systemic medication.